Kosmetische Medizin 4-2009: 142 – 145

Capryloyl Salicylic Acid (CSA) Peel for Acne and Actinic Damage


KEY WORDS: Capryloyl salicylic acid, superficial peel, acne, actinic damage
Capryloyl salicylic acid (CSA) is an ester-derivate with increased lipophily. The compound has corneolytic, anti-inflammatory, anti-microbial and anti-comedonic activities. That makes it an interesting agent for superficial peels. Twenty patients (15 females and 5 males, skin type I-IV) with acne, acne scars or actinic damage have been included in this open clinical trial. All of them underwent a preparation period of two weeks before first peeling with 5 % CSA solution. The peeling was performed twice a month for a total of 4 to 5 treatments. The concentration of CSA was increased to 10 % by the second treatment. By both, patient’s global assessment and physician’s global assessment CSA peel was considered good or better in its clinical effects in 18 of 18 and 17 of 18 patients who completed the series of peels. Two patients dropped out because of intolerance to either the preparation agents or to 5 % CSA. In all other patients the treatment was well tolerated without any serious adverse effect. All patients reported some tingling sensations and desquamation 24 to 48 hours after the procedure. There was no downtime from work. There is some evidence that smoking might negatively affect the efficacy of CSA peel. CSA peel is well tolerated in most patients of skin type I-IV with improvement of inflammatory acne lesions, facial acne scars, radiance, pigmentary changes and
fine wrinkling.