Kosmetische Medizin 1-2010: 16 – 24

NEEDLELESS TRANSDERMAL TISSUE THERAPY – MESOTHERAPY – BY MEANS OF ELECTRICAL FIELD PULSES THEORETICAL PRINCIPLES – EXPERIMENTAL RESULTS – FIRST ANALYSIS
Nadellose transdermale Gewebetherapie – Mesotherapie – mittels elektrischer Feldpulse
THEORETISCHE GRUNDLAGEN – EXPERIMENTELLE ERGEBNISSE – ERSTE ANALYSEN

JÜRGEN WEBER1, UWE PLIQUETT2, ELVIRA MEYER3, HORST NIZZE4, LUDWIG JONAS5,
BURKHARD KRÜGER6, JOHANNES WESSELS7, CHRISTIAN ROSE8

1 Ästhetik-Klinik Dr. Weber und Internationale Akademie, Rostock; 2 Iba-Heilbad Heiligenstadt, Institut für Bioprozeß-und Analysenmeßtechnik e.V., Heilbad Heiligenstadt; 3 Bioserv- Analytik und Medizinprodukte GmbH, Rostock; 4 Universität Rostock, Medizinische Fakultät, Institut für Pathologie, Rostock; 5 Universität Rostock, Medizinische Fakultät, Elektronenmikroskopisches Zentrum (EMZ), Rostock; 6 Universität Rostock, Medizinische Fakultät, AG Medizinische Biologie, Rostock; 7 Universitätsklinikum Göttingen, Zentrum für Innere Medizin, Abt. Nephrologie/Rheumatologie, Göttingen; 8 Universitätsklinikum Lübeck-Klinik für Dermatologie, Allergologie und Venerologie, Lübeck

KEY WORDS: transdermal delivery, needleless mesotherapy, Acthyderm

SUMMARY:
The passage of hydrophilic substances through the very tight stratum corneum (sc) can be improved by the application of certain electrical impulses up to therapeutic relevant amounts. This allows new strategies for a needleless tissue therapy. Quantitative tissue analyis of concentration of active substances and morphological findings demonstrate the positive experiences in the application of such a technology.

Besides the indications in aesthetic medicine, the pain therapy with this method will become important in the future. There are clinical attempts for a lot of indications in the field of dermatological diseases. Further investigations up to transdermal lipolysis with an improved technique and new chemical formulations are necessary to open up the high potential of this technology for more efficiant medical treatments.