Kosmetische Medizin 2-2011: 60-64

GLYCYRRHETIN ACID FROM THE LICORICE ROOT REDUCES THE THICKNESS
OF THE CUTANEOUS FATTY TISSUE AFTER TOPICAL APPLICATION

JENS BIELENBERG

KEY WORDS: Fat reduction, fatty tissue, glycyrrhetin acid, hydrocortisone, licorice root

SUMMARY:
Adults have between 40 an 120 billion fat cells, depending on his physique.The fatty issue does not only serve as a thermo regulator, as a energy reservoir and as a mechanical buffer, but it is also a endocrine organ – a chemical factory – that produces more than 100 active substances, amongst others hydrocortisone that delivers an important impuls for the neoformation of fatty tissue (adipsite differentiation) in the skin. Professor Armanini from Padua, Italy, was able demonstrate that glycyrrhetin acid from the licorice root, reduces cutaneous fatty tissue by inhibiting the hydrocortisone biosynthesis through interaction with the 11-OH-steroid-dehydrogenase [1]. The overall processes in the fatty tissue and the results of the Armanini study on fat reduction by application of a licorice root containing cream are described.

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