Kosmetische Medizin 3-2011: 129-135

PROSPECTIVE DERMATOLOGICALLY CONTROLLED EFFICACY STUDY OF A HYDRATING SPRAY EMULSION WITH 0.2 % ELEMENTAL SILVER IN ATOPIC DERMATITIS
Prospektive dermatologisch kontrollierte Untersuchung der Wirksamkeit einer hydratisierenden Sprühemulsion mit 0,2% elementarem Silber bei Atopischer Dermatitis

UTE GOLBACH, JOHANNES MÜLLER-STEINMANN, STEPHAN HÖHN

KEY WORDS: Atopic dermatitis, spray emulsion, MicroSilver, silver, local SCORAD, SCORAD

SUMMARY:
Objective of the study: Investigation of the efficacy and safety of a sprayable hydrating water-in-oil emulsion with 0.2% silver in 24 patients with mild to moderate atopic dermatitis.
Methods: The primary endpoint was the change in local SCORAD on one selected target skin lesion after four weeks of treatment. The local SCORAD includes five symptoms – erythema, edema and papules, oozing and crusting, excoriation, and lichenification – in the evaluation. The intensity of the individual symptoms is evaluated on a scale from 0 to 3. Secondary endpoints were the change in the SCORAD index (total SCORAD) comprising the clinical picture of all regions affected by atopic dermatitis, the qualitative analysis of bacterial contamination as well as an evaluation of the product and its use from the patient perspective. The patients applied the silver containing spray emulsion themselves twice daily in the morning and evening for four weeks on the selected target lesion. For all other lesions diagnosed during the entry examination patients were asked to use the water-inoil medical skin care milk for sensitive and dry skin that was provided by the sponsor. The first follow-up examination took place after two weeks of treatment and the second and last follow-up examination after four weeks of treatment.
Results: The mean local SCORAD was 5.71 at the start of the study. After two weeks of treatment, it had fallen to 3.90 and after four weeks of treatment it had fallen statistically significantly to 2.06 (reduction: 68.20 % [1]) The mean SCORAD index was 31.88 at the start of the study. After two weeks of treatment, it had fallen to 25.05 and after four weeks of treatment statistically significantly to 15.35 (reduction: 49.99 % [1]). The spray emulsion with silver was evaluated as “Very good” or “Good” by 76.5 % [1] of patients. 82.4 % [1] of patients stated that they would like to continue to use the spray emulsion. Altogether, the silver containing spray emulsion has shown to be an effective, convenient and hydrating treatment of mild to moderate atopic skin conditions.

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