Kosmetische Medizin 3-2011: 108-113

NON INVASIVE FAT REDUCTION:
WHY ARE SOME FAT DEPOSITS TREATMENT RESISTANT?

ILJA KRUGLIKOV1, KLAUS HOFFMANN2

1 Dr. rer. nat. habil. Ilja Kruglikov, WELLCOMET GmbH, Karlsruhe
2 Dr. med. Klaus Hoffmann, Klinik für Dermatologie und Allergologie der Ruhr Universität Bochum, Abteilung Ästhetisch Operative Medizin und kosmetische Dermatologie, Bochum

KEY WORDS: Resistant fat depots, circumference reduction, Hyaluronan, AQP7, TWL-method

SUMMARY:
Lipolytic resistance of some fat depots (especially in gluteo-femoral region) may be connected with regionally specific accumulation of hypertrophic adipocytes which result in over-production of Hyaluronan and accumulation of the bounded water in the tissue in a gel form. Such a structure of extracellular space in the fat tissue forces the adipocytes to inactivate their AQP7 channels to avoid the membrane rupture, thus making these cells “metabolically blind”. This may be the cornerstone in the pathophysiology of lipedema, can explain some treatment problems by patients with obesity and could be essential for the effective non-invasive treatment of resistant fat depots in aesthetic medicine.

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