Kosmetische Medizin 4-2011: 164-174

New technologies for topical delivery and their application in aesthetic dermatology

TAÍS GRATIERI AND YOGESHVAR N. KALIA

KEYWORDS: Microdermabrasion, microporation, laser ablation, iontophoresis, electrophoresis, sonophoresis

SUMMARY:
Active ingredients in cosmeceutical formulations need to reach the viable epidermis or dermis in order to improve skin health. To do this, they must overcome the formidable barrier represented by the outermost layer of the skin, the stratum corneum. Since few active ingredients have the necessary physicochemical properties to readily penetrate the stratum corneum, several techniques have been developed to enhance their delivery; they can be divided into chemical or physical methods. This review presents an overview of the principal physical techniques that have been used to increase topical and transdermal drug delivery and on their application in aesthetic dermatology.

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