Kosmetische Medizin 2013 (1): 20 – 24
CONTROVERSIES IN AESTHETIC MEDICINE: 3. NEOCOLLAGENESIS – “THE UNENDING STORY”
ILJA L. KRUGLIKOV
KEYWORDS: Neocollagenesis, aesthetic treatments, procollagen, mature collagen, turnover
Dermal neocollagenesis is often assumed to be the main reason of visible skin improvement after different non-invasive and minimal invasive aesthetic procedures. However, the very slow dynamics of the mature collagen remodelling within the extra cellular matrix of dermis (with a half-life time of 15 years) renders every observable up-regulation of collagen production insufficient to replace a significant part of the matrix during the short time in which skin improvement is claimed to take place.