Kosmetische Medizin 2013 (1): 20 – 24

CONTROVERSIES IN AESTHETIC MEDICINE: 3. NEOCOLLAGENESIS – “THE UNENDING STORY”

ILJA L. KRUGLIKOV

KEYWORDS: Neocollagenesis, aesthetic treatments, procollagen, mature collagen, turnover

SUMMARY:
Dermal neocollagenesis is often assumed to be the main reason of visible skin improvement after different non-invasive and minimal invasive aesthetic procedures. However, the very slow dynamics of the mature collagen remodelling within the extra cellular matrix of dermis (with a half-life time of 15 years) renders every observable up-regulation of collagen production insufficient to replace a significant part of the matrix during the short time in which skin improvement is claimed to take place.

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